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Darryl C Zeldin Selected Research

Arachidonic Acid (Vitamin F)

1/2019Prediagnostic Serum Levels of Fatty Acid Metabolites and Risk of Ovarian Cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.
1/2018Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.
1/2017Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
5/2016Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.
12/2014CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.
1/2014CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
7/2013Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury.
1/2013Role of endothelial soluble epoxide hydrolase in cerebrovascular function and ischemic injury.
12/2012Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
6/2012Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease.
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Darryl C Zeldin Research Topics

Disease

54Inflammation (Inflammations)
10/2020 - 06/2002
44Asthma (Bronchial Asthma)
10/2020 - 02/2003
18Neoplasms (Cancer)
07/2021 - 06/2005
17Hypertension (High Blood Pressure)
05/2017 - 03/2003
11Ischemia
01/2018 - 09/2004
10Hypersensitivity (Allergy)
05/2019 - 12/2005
9Insulin Resistance
11/2017 - 11/2003
8Reperfusion Injury
05/2020 - 01/2007
8Fibrosis (Cirrhosis)
05/2020 - 09/2007
7Pneumonia (Pneumonitis)
06/2022 - 11/2003
7Hyperemia
01/2020 - 05/2009
7Respiratory Hypersensitivity
04/2017 - 07/2006
6Obesity
01/2021 - 05/2009
6Seasonal Allergic Rhinitis (Hay Fever)
01/2020 - 11/2006
6Cardiovascular Diseases (Cardiovascular Disease)
05/2017 - 06/2012
6Pulmonary Fibrosis (Fibrosing Alveolitis)
11/2011 - 01/2002
5Infections
11/2021 - 06/2004
4Human Influenza (Influenza)
06/2022 - 11/2005
4Lung Diseases (Lung Disease)
01/2018 - 06/2006
4Coronary Artery Disease (Coronary Atherosclerosis)
01/2016 - 10/2004
4Dyslipidemias (Dyslipidemia)
07/2015 - 12/2010
4Cardiomegaly (Heart Hypertrophy)
03/2015 - 01/2013
4Carcinoma (Carcinomatosis)
11/2011 - 06/2005
3Vascular Diseases (Vascular Disease)
01/2020 - 05/2002
3Choroidal Neovascularization
01/2017 - 01/2016
3Pathologic Neovascularization
01/2016 - 03/2014
3Body Weight (Weight, Body)
07/2015 - 07/2009
3Hypertrophy
03/2015 - 01/2013
3Ischemic Stroke
01/2013 - 10/2005
3Diabetic Nephropathies (Diabetic Nephropathy)
09/2012 - 05/2007
3Neoplasm Metastasis (Metastasis)
01/2012 - 07/2007
2Emphysema
06/2022 - 01/2018
2Chronic Bronchitis
06/2022 - 01/2018
2Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 11/2011
2Hemorrhage
01/2021 - 01/2021
2Infarction (Infarctions)
05/2020 - 05/2016
2Carcinogenesis
01/2019 - 01/2012

Drug/Important Bio-Agent (IBA)

40Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
05/2020 - 03/2003
33AllergensIBA
01/2020 - 02/2003
31Cytochrome P-450 CYP2J2 (CYP2J2)IBA
05/2020 - 09/2004
27AcidsIBA
05/2020 - 11/2003
24Epoxide HydrolasesIBA
01/2021 - 10/2005
21EicosanoidsIBA
01/2022 - 05/2002
17Arachidonic Acid (Vitamin F)IBA
01/2019 - 11/2003
13Proteins (Proteins, Gene)FDA Link
09/2020 - 11/2003
12LipidsIBA
01/2022 - 12/2011
12Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
10/2020 - 08/2002
12EnzymesIBA
11/2016 - 08/2002
9CytokinesIBA
11/2021 - 11/2005
9OxylipinsIBA
01/2020 - 01/2016
9EndotoxinsIBA
01/2020 - 12/2005
8Immunoglobulin E (IgE)IBA
01/2018 - 05/2009
8Cytochrome P-450 CYP2C8IBA
11/2016 - 01/2005
7Glucose (Dextrose)FDA LinkGeneric
09/2020 - 04/2010
7Fatty Acids (Saturated Fatty Acids)IBA
01/2019 - 01/2007
6Cyclooxygenase 2 (Cyclooxygenase-2)IBA
01/2016 - 09/2007
6CytochromesIBA
01/2016 - 06/2002
6C-Reactive ProteinIBA
02/2013 - 02/2009
5ProstaglandinsIBA
10/2020 - 11/2005
5Insulin (Novolin)FDA Link
09/2020 - 05/2007
5Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2020 - 12/2016
5cytochrome P-450 CYP2C subfamilyIBA
12/2019 - 10/2003
5Protein Isoforms (Isoforms)IBA
12/2019 - 10/2011
5LipopolysaccharidesIBA
01/2018 - 07/2006
5Streptozocin (Streptozotocin)FDA Link
11/2017 - 05/2007
520-hydroxy-5,8,11,14-eicosatetraenoic acidIBA
05/2017 - 11/2003
5Bleomycin (Blenoxane)FDA LinkGeneric
01/2016 - 09/2007
5Gonadal Steroid Hormones (Sex Hormones)IBA
12/2009 - 01/2007
4Pharmaceutical PreparationsIBA
07/2021 - 05/2009
4Linoleic Acid (Linoleate)IBA
01/2020 - 10/2012
4Dust (House Dust)FDA Link
01/2020 - 12/2005
4Mixed Function Oxygenases (Monooxygenases)IBA
01/2019 - 04/2013
4Biological ProductsIBA
01/2017 - 05/2006
4Retinaldehyde (Retinal)IBA
11/2016 - 08/2013
4Oxygen (Dioxygen)IBA
01/2016 - 06/2006
4CollagenIBA
03/2015 - 09/2007
4OvalbuminIBA
10/2013 - 06/2010
4FructoseIBA
04/2010 - 11/2003
3AntioxidantsIBA
06/2022 - 11/2011
3Cyclooxygenase 1IBA
01/2021 - 11/2005
3Dinoprostone (PGE2)FDA Link
01/2020 - 11/2005
3ORALIT (ORS)IBA
01/2020 - 11/2006
3Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
01/2017 - 03/2014
3Peroxisome Proliferator-Activated Receptors (PPAR)IBA
11/2016 - 12/2014
314,15-epoxy-5,8,11-eicosatrienoic acidIBA
01/2015 - 02/2010
3Angiotensin IIIBA
01/2014 - 10/2003
3Antihypertensive Agents (Antihypertensives)IBA
09/2012 - 04/2010
3Prostaglandins EIBA
11/2011 - 08/2002
3AngiotensinsIBA
10/2010 - 03/2003
3SaltsIBA
10/2010 - 03/2003
3Nitric Oxide (Nitrogen Monoxide)FDA Link
02/2009 - 06/2004
3Tissue Kallikreins (Tissue Kallikrein)IBA
04/2008 - 11/2003
2Protein Kinases (Protein Kinase)IBA
01/2021 - 05/2007
2Adenosine (Adenocard)FDA LinkGeneric
01/2021 - 05/2007
2BradykininIBA
11/2020 - 04/2008
2Reactive Oxygen Species (Oxygen Radicals)IBA
05/2020 - 11/2011
2Prostaglandin D2IBA
01/2020 - 05/2019
2Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
01/2020 - 01/2017

Therapy/Procedure

9Therapeutics
11/2017 - 05/2006
2Nebulizers and Vaporizers (Inhaler)
10/2020 - 05/2018